A TaqI RFLP identified at the retinoblastoma locus on chromosome 13
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A TaqI RFLP identified at the retinoblastoma locus on chromosome 13.
SOURCE/DESCRIPTION: Probe D95HS0.5 is a 0.6 kb fragment subcloned into Blue-scribe a pUCl9 derivative from a bacterio phage library isolated by a cDNA probe of the retinoblastoma gene 1. The fragment is released with the enzymes Hindlll and Sail. POLYMORPHISMS: TaqI identifies a 2 allele polymorphism with a band at 2.1 kb and 1.8 kb with a frequency of 0.97 and 0.03 respectively. There are no c...
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Chromosomal Localization: The 3 polymorphic bands were mapped to chromosome 22 using a somatic cell hybrid panel. The 2.1 kb constant band mapped to chromosome lq whereas all other constant bands mapped to chromosome 20. Whereas the active gene for hTOPl is located on chromosome 20ql 1.2—13.1, two pseudogenes are on chromosomes Iq23—24 and 22qll.2-13.1 (2). The sequences of hTOPl and the two ps...
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A polymorphism of D13S86 from the region 13q14.1 to 13q22 N.P.McHaffie-, R.Houwen,' + , W.Cavenee and D.W.Cox. 2 * 1 Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, department of Medical Genetics, University of Toronto, Toronto and Ludwig Institute for Cancer Research, Montreal, Canada A high-frequency RFLP at the human TFE3 locus on the X ch...
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Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice f...
متن کاملAva I RFLP at the gas-1 locus on mouse chromosome 12.
SOURCE/DESCRIPTION A family of G-specific genes vhose expression is negatively regulated by serum and growth factor has been called gas (growth-arrest-spp.cif lc genes). A fragment of 1.3 Kb of gas-1 cDNA cloned in a EcoRI site of Blue script vector vas used as probe. POLYMORPHISM After DNA digestion with Ava I a constant band of 4.9 Kb and a variant band of 5.4 Kb were observed. FREQUENCY The ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1988
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/16.18.9069